Paolo Macchiarini Birthday, Date of Birth

Paolo Macchiarini (born 22 August 1958) is a thoracic surgeon and former regenerative medicine researcher who became known for research fraud and manipulative behavior. He was convicted of research-related crimes in Italy and Sweden.

Previously considered a pioneer for using both biological and synthetic scaffolds seeded with patients' own stem cells as trachea transplants, Macchiarini was a visiting professor and director on a temporary contract at Sweden's Karolinska Institutet (KI) from 2010. Macchiarini was convicted of unethically performing experimental surgeries, even on relatively healthy patients, resulting in fatalities for seven of the eight patients who received one of his synthetic trachea transplants. Articles in Vanity Fair and Aftonbladet further suggested he had falsified some academic credentials on résumés.

Urban Lendahl, the secretary of the Nobel Committee for Physiology or Medicine, resigned in February 2016, owing to his involvement in recruiting Macchiarini to KI. Shortly afterwards KI's vice chancellor, Anders Hamsten, who in 2015 had cleared Macchiarini of misconduct, resigned. KI terminated its clinical relationship with Macchiarini in 2013 but allowed him to continue as a researcher; in February 2016, the university announced it would not renew his research contract, which was due to expire in November, and terminated the contract the following month. After being dismissed from KI, Macchiarini worked at the Kazan Federal University in Russia until that institution terminated his project in April 2017, effectively firing him.

After a one-year medico-legal investigation, the Swedish Prosecution Authority announced in October 2017 that Macchiarini had been negligent in four of the five cases investigated, due to the use of devices and procedures not supported by evidence, but a crime could not be proven because the patients might have died under any other treatment given. Macchiarini was convicted of causing bodily harm, but not assault. He received a suspended sentence in June 2022. However, a year later his sentence was increased to two years and six months imprisonment by an appeals court. Following an appeal to the Supreme Court, the Court declined to consider the appeal in October 2023.

Sweden's Expert Group on Scientific Misconduct found evidence of research fraud by Macchiarini and his co-authors in six papers and called for them to be retracted. As of 2023, Macchiarini has had 11 of his research papers retracted, four others have received an expression of concern, and three others have been corrected.

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